This invention through the preservation moisture effect of the skin, vis-a-vis the decrease of the skin function which happens with various causes, designates that the useful new medicine is offered to the remedy which improves the skin characteristics of skin drying, the rough skin and the being somber etc which accompanies keratin incrassating as purpose. This invention, the chemical compound which possesses the moruhinan framework of the specification which is represented in the chemical compound 1 which is displayed with below-mentioned structural formula (ii), or is something which offers the skin characteristics improvement remedy which designates acid attaching salting which that pharmacology is allowed as the active ingredient. < Conversion 1 >本発明は、様々な原因で起こる皮膚機能の低下に対して、皮膚の保湿効果を介して皮膚乾燥、肌荒れ、角質肥厚に伴うくすみ等の皮膚性状を改善する治療に有用な新規薬剤を提供することを目的とする。本発明は、下記の構造式(II)で表される化合物1に代表される特定のモルヒナン骨格を有する化合物、またはその薬理学的に許容される酸付加塩を有効成分とする皮膚性状改善治療薬を提供するものである。【化1】
