KIRVIN L. HODGE,REID W. VON BORSTEL,SHALINI SHARMA,STEPHEN D. WOLPE
申请号：
BRPI0409469
公开号：
BRPI0409469B1
申请日:
2004.04.08
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"compounds for the treatment of metabolic disorders". agents used for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed: wherein n is 1 or 2； m is 0, 1, 2, 3 or 4； q is 0 or 1； t is 0 or 1； R2 is alkyl having from 1 to 3 carbon atoms； R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms； a is phenyl unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms and perfluoromethoxy； or cycloalkyl having from 3 to 6 ring carbon atoms, wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl； or a 5- or 6-membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from n, s and 0 and the heteroaromatic ring is covalently attached to the remainder of the compound of formula i by a ring carbon； and R2 is hydrogen or alkyl having 1 or 2 carbon atoms, provided that when m is o or 1, R2 is not hydrogen. alternatively, when R1 is hydrogen, the biologically active agent may be a pharmaceutically acceptable salt of the compound of formula i."compostos para o tratamento de distúrbios metabólicos". agentes usados para o tratamento de vários distúrbios metabólicos, tais como síndrome de resistência à insulina, diabetes, hiperlipidemia, doença do fígado gorduroso, caquexia, obesidade, aterosclerose e arteriosclerose são divulgados: em que n é 1 ou 2； m é 0, 1, 2, 3 ou 4； q é 0 ou 1； t é 0 ou 1； r^ 2^ é alquila tendo de 1 a 3 átomos de carbono； r^ 3^ é hidrogênio, halo, alquila tendo de 1 a 3 átomos de carbono ou alcóxi tendo de 1 a 3 átomos de carbono； a é fenila não substituída ou substituída por 1 ou 2 grupos selecionados de: halo, alquila tendo 1 ou 2 átomos de carbono, perfluorometila, alcóxi tendo 1 ou 2 átomos de carbono
