Esteban Masuda,Rajinder Singh,Vanessa Taylor,Donald G. Payan
申请号：
US14750794
公开号：
US09890144B2
申请日:
2015.06.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula Iwherein X and Y independently are O or NR1； each R1 is independently H or C1-C6 alkyl； ring A is aryl； each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system； p is 0, 1, 2, 3, or 4； R3 and R4 independently are H or C1-C6 alkyl； and R5 is halo, cyano, or C1-C6 alkyl.
