Production of glycoproteins with reduced O-glycosylation

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专利权人:

Piotr Bobrowicz

发明人:

Piotr Bobrowicz,W. James Cook,Warren Kett

申请号：

US13484665

公开号：

US08501438B2

申请日:

2012.05.31

申请国别(地区):

US

年份:

2013

代理人:

摘要：

A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

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中国工程科技知识中心

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