COMPOSITIONS AND METHODS FOR TREATING SYNUCLEINOPATHIES

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专利权人:

BIOGEN INTERNATIONAL NEUROSCIENCE GMBH

发明人:

PENNER, Natasha,MURALIDHARAN, Kumar Kandadi

申请号：

SG11201908672W

公开号：

SG11201908672WA

申请日:

2018.03.30

申请国别(地区):

SG

年份:

2019

代理人:

摘要：

1 5 60 C c3) 20 I- EC9O (2.1 nM Low (EC50 0.25nM) 40 0 0.0001 0.001 0.01 0.1 1 10 100 Dose response ran 100 igh - >；EC90, target binding plateau (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT °mono n o oloinoin loolioluo VII IE (10) International Publication Number WO 2018/178950 Al (51) International Patent Classification: C07K 16/18 (2006.01) A61P 25/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/IB2018/052236 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,818 31 March 2017 (31.03.2017) US 62/528,790 05 July 2017 (05.07.2017) US (71) Applicant: BIOGEN INTERNATIONAL NEU- ROSCIENCE GMBH [CH/CH]； Landis + Gyr-Strasse 3, 6300 Zug (CH). (72) Inventors: PENNER, Natasha； 23 Tanglewood Rd., New- ton, Massachusetts 02459 (US). MURALIDHARAN, Ku- mar Kandadi； 235 Arboretum Way, Burlington, Massa- chusetts 01803 (US). (74) Agent: CONROY, John, F.； Fish & Richardson P.C., Highlight Business Towers, Mies-van-der-Rohe-Strasse 8, D-80807 Mfinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA,

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