PROBLEM TO BE SOLVED: To provide an immune normal animal other than man having a structure peculiar to cancer tissue.SOLUTION: A cancer cell is cultured in a temperature range of weak hydration force of a polymer on a cell culture support whose surface is coated with a polymer with variable hydration force in a temperature range of 0-80°C. A culture solution is then changed to a temperature to obtain a state of strong hydration force of the polymer to strip the cultured cancer cell, and the cancer cell is transplanted to a predetermined site of the transplantation object animal to acquire the immune normal animal other than man having the structure peculiar to cancer tissue.COPYRIGHT: (C)2013,JPO&INPIT【課題】癌組織特有の構造を有したヒト以外の免疫正常動物を提供する。【解決手段】0~80℃の温度範囲で水和力が変化するポリマーを表面に被覆した細胞培養支持体上で、ポリマーの水和力の弱い温度域で癌細胞を培養し、その後、培養液をポリマーの水和力の強い状態となる温度に変化させることで培養した癌細胞を剥離させ、移植対象となる動物の所定部位に移植した、癌組織特有の構造を有したヒト以外の免疫正常動物。【選択図】なし
