The Research Foundation for the State of University New York
发明人:
Sabine M. Brouxhon,M. Kerry O'Banion,Stephanos Kyrkandies
申请号：
US16256800
公开号：
US20190352380A1
申请日:
2019.01.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof； expression vectors and cells for expressing such polypeptides； and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof； method of generating agents, such as antibodies, that target these polypeptides； and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence.
