Yvonne L. Flanders;Carmen M. Baldino;Justin L. Caserta;Stephane A. Dumas;Chee-Seng Lee
发明人:
Carmen M. Baldino,Justin L. Caserta,Stephane A. Dumas,Chee-Seng Lee,Yvonne L. Flanders
申请号：
US13452250
公开号：
US20120270892A1
申请日:
2012.04.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.
