BALDINO, CARMEN M.,CASERTA, JUSTIN L.,LEE, CHEE-SENG,DUMAS, STEPHANE A.,FLANDERS, YVONNE L.
申请号：
CA2853454
公开号：
CA2853454A1
申请日:
2012.10.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed are aminopyrimidine compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK 1, CKIyl, CKIy2, CKIy3, CK2, Pim 1, Pim2, Pim3, the TGFß pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. Uses arc also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of CK1, CKIyl, CKIy2, CKIy3, CK2, Pim 1, Pim2, Pim3, the TGFß pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway.
