SOANE, DAVID S.,WUTHRICH, PHILIP,MAHONEY, ROBERT P.,MOODY, MARK,GREENE, DANIEL G.,SCHAUER, NEIL L.
申请号：
CA3053909
公开号：
CA3053909A1
申请日:
2018.02.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.
