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Compressed tablets comprising microcapsules with modified release
专利权人:
Rafaël Jorda
发明人:
Rafaël Jorda,Pierre Autant
申请号:
US10507886
公开号:
US08507003B2
申请日:
2003.03.14
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
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