INDIAN INSTITUTE OF SCIENCE;MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
发明人:
Steven A. ROSENZWEIG,Hanudatta S. ATREYA,Asampilli GITANJALI,Paturu KONDAIAH
申请号：
US16724436
公开号：
US20200206313A1
申请日:
2019.12.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye.
