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PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
专利权人:
The Brigham and Women's Hospital; Inc.;The Brigham and Womens Hospital
发明人:
Lee, Richard,Segers, Vincent
申请号:
AU2013234365
公开号:
AU2013234365B2
申请日:
2013.09.26
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2013234365B220160519.pdf#####ABSTRACT The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
来源网站:
中国工程科技知识中心
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