Ralph A. Chappa,Robert W. Hergenrother,Shannon A. Wadman,Klaus R. Wormuth
申请号：
US12386469
公开号：
US08496954B2
申请日:
2009.04.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
