University of Pittsburgh - of the Commonwealth System of Higher Education
发明人:
WEI QIAN,Peter Wipf,Bennett Van Houten
申请号:
US15380776
公开号:
US20170095478A1
申请日:
2016.12.15
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.