PROBLEM TO BE SOLVED: To provide a compound that regulates functions of TRPV1 receptor, a TRV1 receptor regulating agent having a derivative of the compound as an active ingredient, and to provide a preventive and therapeutic agent for diseases with sharp pain relating to TRPV1 receptor.SOLUTION: The compound represented by formula (I) and a salt thereof, a solvate of the compound, and a pharmaceutical composition which contains the compound, salt or solvate as effective ingredients are disclosed. In the formula, n represents an integer of 0 to 2 R1 represents a halogen atom, an optionally substituted hydrocarbon group, a heterocyclic group or the like R2 represents a hydrogen atom, an optionally substituted 1 to 4C alkyl group or a 1 to 4C alkoxyl group R4 and R5 each independently represent a hydrogen atom, a 1 to 4C alkyl group or a phenyl group Q represents an optionally substituted aryl group or a heterocyclic group and Z represents =CR6- or =N-.COPYRIGHT: (C)2012,JPO&INPIT【課題】TRPV1受容体の機能を調節する化合物、該誘導体を有効成分とするTRPV1受容体調節剤、疼痛を含むTRPV1受容体が関与する疾患の予防・治療剤の提供。【解決手段】式(I)(式中、nは、0~2の整数を表し;R1は、ハロゲン原子、置換されてもよい炭化水素基、ヘテロ環基等を表し;R2は、水素原子、置換されてもよいC1~4のアルキル基またはC1~4のアルコキシル基を表し;R4及びR5は、各々独立に、水素原子、C1~4のアルキル基またはフェニル基を表し;Qは、置換されていてもよいアリール基またはヘテロ環基を表し;Zは、=CR6-または=N-を表す。)で表される化合物、その塩、それらの溶媒和物、これらを有効成分とする医薬組成物。【選択図】なし
