Provided is an immunogenic composition comprising 15 different polysaccharide-protein conjugate. Each of the conjugates comprises a capsular polysaccharide prepared from different serotype Streptococcus pneumoniae conjugated to a carrier protein, that is, serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F and 23F. An immunogenic composition formulated into a vaccine comprising an aluminum-based adjuvant increases the application range with respect to pneumococcal diseases in infants and children.L'invention concerne une composition immunogénique comprenant 15 conjugués polysaccharide-protéine différents. Chacun des conjugués comprend un polysaccharide capsulaire, préparé à partir de Streptococcus pneumoniae de différents sérotypes, c'est-à-dire, les sérotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F et 23F, conjugué à une protéine support. Une composition immunogénique formulée dans une composition de vaccin comprenant un adjuvant à base d'aluminium augmente le champ d'application relatif aux maladies à pneumocoque chez les nourrissons et les enfants.15개의 상이한 다당류-단백질 접합체를 포함하는 면역원성 조성물이 기술된다. 각 접합체는 운반체 단백질에 접합된 상이한 혈청형의 스트렙토코커스 뉴모니애 즉, 혈청형 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F 및 23F로부터 제조된 협막 다당류를 포함한다. 알루미늄계 애쥬번트를 가진 백신으로 제제화된 면역원성 조성물은 유아 및 소아에서 폐렴구균 질환에 대한 적용범위를 증가시킨다.
