GREIG, IAIN ROBERT,SHERIDAN, ROSE MARY,FISHER, RAYMOND,TOZER, MATTHEW JOHN,CLASE, JUHA ANDREW,SMITH, ANDREW,TUFFNELL, ANDREW ROBERT,VAN 'T HOF, ROBERT JURGEN
申请号：
CA2736971
公开号：
CA2736971C
申请日:
2009.09.18
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention pertains generally to the field of therapeuticcompounds, and more specifically to certainaryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula(collectively referred to herein as "APSACcompounds"). The present invention also pertains to pharmaceuticalcompositions comprising such compounds, and the use ofsuch compounds and compositions, both in vitro and in vivo, in treatment, forexample, of inflammation and/or joint destructionand/or bone loss； of disorders mediated by excessive and/or inappropriateand/or prolonged activation of the immune system； ofinflammatory and autoimmune disorders, for example, rheumatoid arthritis,psoriasis, psoriatic arthritis, chronic obstructive pulmonarydisease (COPD), atherosclerosis, inflammatory bowel disease, ankylosingspondylitis, and the like； of disorders associatedwith bone loss, such as bone loss associated with excessive osteoclastactivity in rheumatoid arthritis, osteoporosis, cancer-associatedbone disease, Paget's disease and the like, etc.； and of cancer, such as ahaematological malignancy, a solid tumour, etc. Formula (I).
