GREIG, IAIN ROBERT,SHERIDAN, ROSE MARY,FISHER, RAYMOND,TOZER, MATTHEW JOHN,CLASE, JUHA ANDREW,SMITH, ANDREW,TUFFNELL, ANDREW ROBERT,VAN 'T HOF, ROBERT JURGEN
申请号：
CA2736980
公开号：
CA2736980C
申请日:
2009.09.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention pertains generally to the field of therapeuticcompounds, and more specifically to certainaryl-phenyl-sulfonamido-phenylene compounds of the following formula (I)(collectively referred to herein as "APSAP compounds").The present invention also pertains to pharmaceutical compositions comprisingsuch compounds, and the use of suchcompounds and compositions, both in vitro and in vivo, in treatment, forexample, of inflammation and/or joint destruction and/orbone loss； of disorders mediated by excessive and/or inappropriate and/orprolonged activation of the immune system； of inflammatoryand autoimmune disorders, for example, rheumatoid arthritis, psoriasis,psoriatic arthritis, chronic obstructive pulmonarydisease (COPD), atherosclerosis, inflammatory bowel disease, ankylosingspondylitis, and the like； of disorders associated withbone loss, such as bone loss associated with excessive osteoclast activity inrheumatoid arthritis, osteoporosis, cancer-associatedbone disease, Paget's disease and the like, etc.； and of cancer, such as ahaematological malignancy, a solid tumour, etc.
