PROBLEM TO BE SOLVED: To provide a method applied to plant extract difficult to granulate for manufacturing a granule with intraoral instant solubility having little feeling of bitterness which can be easily taken without water.SOLUTION: A method for manufacturing a granule with intraoral instant solubility including plant extract comprises a step of adding and kneading an aqueous medium to a powder mixture including plant extract, sugar alcohol, and starch and a step of pushing out and granulating the kneaded powder mixture, in which the water content of the kneaded powder mixture is more than 5.1 wt.% and less than 8.9 wt.%.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】顆粒化が難しい植物抽出物を対象とし、口腔内で即時に溶解し、苦みを感じにくく、水なしでも簡便に服用できる顆粒を製造する方法を提供すること。【解決手段】植物抽出物と糖アルコールと澱粉を含む粉末混合物に、水性媒体を添加して練合する工程と、練合後の粉末混合物を押し出し造粒する工程を含み、練合後の粉末混合物の水分量が5.1重量%より多く8.9重量%未満であることを特徴とする、植物抽出物を含有する口腔内即溶性顆粒の製造方法。【選択図】なし
