PROCESSES FOR THE PREPARATION OF CABAZITAXEL INVOLVING C(7)-OH AND C(13)-OH SILYLATION OR JUST C(7)-OH SILYLATION

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专利权人:

Fresenius Kabi Oncology Limited

发明人:

申请号：

EP12783667.4

公开号：

EP2760848B1

申请日:

2012.09.21

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Disclosed are processes towards Cabazitaxel (I) starting from 10-Deacetylbaccatin (III) that involve steps of either 7-OH monosilylation (passing through formula V) or 7,13-disilylation (passing through formulae XI, XII). Isopropanol Solvates of Cabazitaxel and processes to make this are also described.

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