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共加工された錠用賦形剤混合物、その調製及び使用
专利权人:
フリースランドカンピナ・ネーデルランド・ホールディング・ビー.ブイ.
发明人:
ファン・ゲゼル、アレクサンダー・ビルヘルムス
申请号:
JP2012544418
公开号:
JP5714600B2
申请日:
2010.12.16
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The invention pertains to a co-processed excipient composition suitable for tableting, said composition comprising at least one filler-binder, at least one disintegrant, and at least one lubricant which have been subjected to granulation together, and said composition partially or completely coated with lactose, preferably in crystalline form. The inventors have overcome the prejudice against the use of lubricants in tableting excipient compositions early in the tableting process. It was found that the alleged detrimental affects of the lubricant in terms of binding and disintegration could readily be controlled in a excipient composition wherein the lubricant is co-processed in the matrix, and the composition is provided with a lactose coat.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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