The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.本發明提供藉由向患者投與治療有效量之丁基原啡因二聚體化合物來治療外周神經痛之方法及組合物，其中該等兩個丁基原啡因部分係經由伸乙基間隔基聯結，且其中該間隔基係經由醚鍵鍵結至兩個類鴉片分子。較佳地，該活性劑係以可注射積存劑形式提供。
