Yusuf A. Hannun;Zdzislaw M. Szulc;Aiping Bai;Liu Xiang;Alicja Bielawska;James S. Norris
发明人:
Alicja Bielawska,Aiping Bai,Zdzislaw M. Szulc,Yusuf A. Hannun,James S. Norris,Liu Xiang
申请号：
US13127888
公开号：
US08697379B2
申请日:
2009.11.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.
