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PEPTIDE BIOMIMÉTIQUE ET PLATEFORME D'ADMINISTRATION BIODÉGRADABLE UTILISABLES EN VUE DU TRAITEMENT DE MALADIES ASSOCIÉES À L'ANGIOGENÈSE ET À LA LYMPHANGIOGENÈSE
专利权人:
The Johns Hopkins University
发明人:
申请号:
EP14807179.8
公开号:
EP3003343B1
申请日:
2014.06.09
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence LRRFSTAPFAFIDINDVINF, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. The isolate peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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