Provided herein are methods for selecting and treating a subject with leukemia, wherein the subject is selected for treratment and is treated with an MDM2 inhibitor because said subjects cells contain an FLT3-ITD mutation.本發明係提供用於選擇及治療白血病患者的方法,其中該患者係經選擇而治療且係以MDM2抑制劑治療,因為該患者之細胞含有FLT3-ITD突變。