The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.本發明提供監測生物標記之差異性基因表現以確定患者對Wnt抑制劑敏感性之方法、藉由測量生物標記確定細胞對Wnt抑制劑敏感性之方法、對於候選Wnt抑制劑之篩選方法、用於頭部及頸部鱗狀細胞癌之Wnt抑制劑。
