Steven J. Demarco,Kerstin Moehle,Heiko Henze,Odile Sellier,Francoise Jung,Frank Gombert,Daniel Obrecht,Christian Ludin
申请号：
US15170233
公开号：
US10100084B2
申请日:
2016.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Template-fixed β-hairpin peptidomimetics of the general formulaewherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
