Jürg Zumbrunn,Steven J. Demarco,Sergio Lociuro,Jan Wim Vrijbloed,Frank Gombert,Reshmi Mukherjee,Kerstin Moehle,Daniel Obrecht,John Anthony Robinson,Heiko Henze,Barbara Romagnoli,Christian Ludin
申请号:
US14495737
公开号:
US09518092B2
申请日:
2014.09.24
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Template-fixed β-hairpin peptidomimetics of the general formula (I)wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.