Matthew J. Bernett,Seung Yup Chu,John R. Desjarlais,Sher Bahadur Karki,Gregory Alan Lazar,Erik WeiKing Pong,Eugene Alexander Zhukovsky
申请号：
US12864075
公开号：
US08551485B2
申请日:
2009.01.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
