ACCETTA, ALESSANDRO,RANCATI, FABIO,CAPELLI, ANNA MARIA,CLARK, DAVID EDWARD,TISSELLI, PATRIZIA,EDWARDS, CHRISTINE,CHEGUILLAUME, ARNAUD JEAN FRANCOIS AUGUSTE,BHALAY, GURDIP
申请号：
CA3047212
公开号：
CA3047212A1
申请日:
2018.01.26
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
