The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having an endocrine disorder characterized by partial endogenous growth hormone activity or signaling. The invention provides a method comprising administering to a patient suffering from an endocrine disorder characterized by partial endogenous growth hormone activity or signaling an amount of insulin-like growth factor-1 (IGF-1) effective to improve metabolism in the patient, where the patient receives IGF-1 in a single daily administration. The invention also provides a method comprising administering to a patient suffering from an endocrine disorder characterized by partial endogenous growth hormone activity or signaling an amount of insulin-like growth factor-1 (IGF-1) and an amount of growth hormone (GH) that in combination are effective to improve growth or metabolism in the patient, where the patient receives IGF-1 in a single daily administration and receives GH in a single daily administration, and where the single IGF-1 administration and the single GH administration are administered to the patient substantially contemporaneously each day.Linvention concerne des méthodes et des compositions permettant daugmenter les taux de croissacne, datténuer les symptômes ou daméliorer le métabolisme de patients humains souffrant dun trouble endocrinien caractérisé par lactivité ou la signalisation partielle dune hormone de croissance. Linvention concerne une méthode qui consiste à administrer à un patient souffrant dun trouble endocrinien caractérisé par une activité ou une signalisation partielle dune hormone de croissance une quantité efficace de facteur de croissance 1 (IGF-1) du type insuline afin daméliorer le métabolisme de ce patient, ledit patient recevant IGF-1 par administration quotidienne unique. Linvention concerne également une méthode qui consiste à administrer à un patient souffrant dun troubl
