Disclosed herein is a method of producing collagen particles. Each of the collagen particle is characterized in having a particle size of about 10-250 μm, in which the integrity of collagen fibers therein is relatively intact.在此揭示一種製備膠原蛋白顆粒的方法。每一膠原蛋白顆粒的顆粒尺寸為約10-250微米,且顆粒中所含的膠原纖維結構相對完整。