PROBLEM TO BE SOLVED: To provide a novel compound inhibiting one or more protein kinase activity for treatments of various diseases, disorders and symptoms, and therapeutic means.SOLUTION: There is provided a novel pyrimido-diazepinone compound. There is related to an adjustment method of protein kinases such as MPS1(TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3 or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl variant, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, TrkC, and an application of such compound in treatments of various diseases, disorders and symptoms.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】様々な疾患、障害および症状の治療のための、１つ以上のタンパク質キナーゼ活性を阻害する新規化合物及び治療手段の提供。【解決手段】新規ピリミド－ジアゼピノン化合物。並びにＭＰＳ１（ＴＴＫ）、ＥＲＫ５（ＢＭＫ１、ＭＡＰＫ７）、ＬＲＫＫ２、ＥｐｈＡ２、ポロキナーゼ１、２、３、または４、Ａｃｋ１、Ａｃｋ２、Ａｂｌ、ＤＣＡＭＫＬ１、ＡＢＬ１、Ａｂｌ変異体、ＤＣＡＭＫＬ２、ＡＲＫ５、ＢＲＫ、ＭＫＮＫ２、ＦＧＦＲ４、ＴＮＫ１、ＰＬＫ１、ＵＬＫ２、ＰＬＫ４、ＰＲＫＤ１、ＰＲＫＤ２、ＰＲＫＤ３、ＲＯＳ１、ＲＰＳ６ＫＡ６、ＴＡＯＫ１、ＴＡＯＫ３、ＴＮＫ２、Ｂｃｒ－Ａｂｌ、ＧＡＫ、ｃＳｒｃ、ＴＰＲ－Ｍｅｔ、Ｔｉｅ２、ＭＥＴ、ＦＧＦＲ３、Ａｕｒｏｒａ、Ａｘｌ、ＴｒｋＣ等のタンパク質キナーゼの調節方法、ならびに様々な疾患、障害および症状の治療におけるこのような化合物の使用に関する。【選択図】なし
