Molecular targets and compounds and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP11154125.6

公开号：

EP2360478B1

申请日:

2005.10.17

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter "TARGETS") and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/