Richard BÉLIVEAU,Borhane ANNABI,Michel DEMEULE,Alain LAROCQUE,Jean-Christophe CURRIE,Sylvie LAMY
申请号：
US16616098
公开号：
US20200157151A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating inflammation. For example, the compounds can comprise compounds； IKLSGGVQAKAGVINMDKSESM, formula (V) as set forth in SEQ ID NO: 5, GVRAKAGVRN(Nle)FKSESY, formula (X) as set forth in SEQ ID NO: 10 and YKSLRRK.APRWDAPLRDPALRQLL, formula (XI) as set forth in SEQ ID NO: 11 wherein at least one protecting group and/or at least one labelling agent is connected to said peptide compound at an N- and/or C-terminal end, for use in inhibiting or decreasing TNF-alpha-induced COX-2 expression in cells expression sortilin.
