The purpose of this study was to test the efficacy of an oregano extract containing carvacrol and capyrlic acid blend by screening for inhibition and by conducting a preservative efficacy test, USP 51, in skin creams. Minimum inhibitory concentrations were found for Escherichia coli, Staphylococcus aureus, Pseudomonsas aeruginosa, Streptococcus sanguinis, Salmonella enterica, Candida albicans, and Aspergillus brasiliensis.