[Object]To provide a biological adhesive sheet which is reduced in the influence on a living organism and thus has improved safety.[Solution]A biological adhesive sheet (10) which has: a substrate (12) that is formed of a biocompatible material; and a plurality of projections (13) that are formed of a biocompatible material and configured so as to protrude from the surface of the substrate (12). The biological adhesive sheet (10) is bonded to living tissues by the van der Waals force by having the plurality of projections (13) in contact with the living tissues.