A misting device with quick release interchangeable cartridge is disclosed for atomizing and discharging a composition as a mist for topical application of the composition to the body or diffusing the composition into the ambient air. The cartridge comprises an atomizer and quickly attaches and detaches from a body using a coupling mechanism which may create a friction fit engagement. The atomizer atomizes the composition. A base maintains the body in an upright position for formulation of the composition in the cavity of the cartridge.