A bioadhesive formulation comprising gelatin alginate and a coupling agent capable of forming a bioadhesive matrix which is characterized by rapid curing optimal viscosity high bonding strength flexibility biocompatibility and biodegradability is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent and a drug eluting bioadhesive matrix formed therefrom the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.
