The present invention comprises (i) a VHCDR1 having the amino acid sequence GNTFTSYVMH, a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG, and a heavy chain variable domain containing the VHCDR3 having the amino acid sequence STARATPYFYAMDY, and (ii) a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, and an amino acid sequence GASIRES. And a light chain variable domain comprising VLCDR3 having the amino acid sequence QHNHGSFLPYT, and an antigen-binding protein that binds to CEACAM6 or an antigen-binding fragment thereof. The present invention also provides a composition comprising an antigen-binding protein or an antigen-binding fragment thereof for treating, preventing or detecting cancer, a method of using the antigen-binding protein or an antigen-binding fragment thereof, and an antigen-binding protein or an antigen-binding fragment thereof. It also relates to kits that include.本発明は、(i)アミノ酸配列GNTFTSYVMHを有するVHCDR1、アミノ酸配列YINPYNDGTKYNEKFKGを有するVHCDR2、及びアミノ酸配列STARATPYFYAMDYを有するVHCDR3を含む重鎖可変ドメインと、(ii)アミノ酸配列KSSQSLLWSVNQNSYLSを有するVLCDR1、アミノ酸配列GASIRESを有するVLCDR2、及びアミノ酸配列QHNHGSFLPYTを有するVLCDR3を含む軽鎖可変ドメインとを含む、CEACAM6に結合する抗原結合タンパク質又はその抗原結合断片に関する。本発明はまた、がんの治療、予防又は検出のための抗原結合タンパク質又はその抗原結合断片を含む組成物、抗原結合タンパク質又はその抗原結合断片の使用方法及び抗原結合タンパク質又はその抗原結合断片を含むキットにも関する。
