Singapore Health Services PTE LTD;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人:
Hau Wan LEUNG,Andre Boon Hwa CHOO,Mei Yee vanessa DING,Shao Weng Daniel Tan,Narayanan Gopalakrishna Iyer
申请号：
US16341052
公开号：
US20190233514A1
申请日:
2017.10.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH； a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG； and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
