A protein selected from the amino acid sequence of the region valine Val(91)to glycineGly(121) of the mature human tumour necrosis factor, or a portion thereof,with the provisothat the protein comprises at least the amino acid sequence of the regionlysine Lys(98) toglutamic acid Glu(116), with the cysteine Cys(101) being replaced by a glycineand anamide bond being formed between the amino group of the side chain of thelysine Lys(98)and the carboxyl group of the side chain of the glutamic acid Glu(116), whichactivatesepithelial ion channels and improves the lung function and which can be usedfor themanufacture of medicaments for the treatment of diseases associated with thelung function,such as oedemas.
