Ethyl 3-?á(2-?í?á4-Hexyloxycarbonylamino-imino-methyl)-phenylamino?å-methyl?ç-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino?å-propionate methanesulfonate hemihydrate and its use as a medicament

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

SIEGER PETER,SOBOTTA RAINER,SCHMID ROLF

申请号：

SI200431794

公开号：

SI2060569T1

申请日:

2004.08.24

申请国别(地区):

SI

年份:

2012

代理人:

摘要：

Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180+-3[deg]C, 190+-3[deg]C and 120+-5[deg]C respectively, are new. Independent claims are also included for the preparation of (Ia)-(Ic). ACTIVITY : Anticoagulant Cerebroprotective Vasotropic. No biological data is given. MECHANISM OF ACTION : Thrombin inhibitor.

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