Hemihydrat metanosulfonianu estru etylowego kwasu 3-[(2-{[4-heksylokarbonyloamino-imino-metylo)-fenyloamino]-metylo}-1-metylo-1H-benzimidazolo-5-karbonylo)-pirydyn-2-ylo-amino]-propionowego i jego zastosowanie jako leku

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专利权人:

Boehringer Ingelheim International GmbH

发明人:

SIEGER, PETER,SOBOTTA, RAINER,SCHMID, ROLF

申请号：

PL09153155

公开号：

PL2060569T3

申请日:

2004.08.24

申请国别(地区):

PL

年份:

2012

代理人:

摘要：

Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180+-3[deg]C, 190+-3[deg]C and 120+-5[deg]C respectively, are new. Independent claims are also included for the preparation of (Ia)-(Ic). ACTIVITY : Anticoagulant； Cerebroprotective； Vasotropic. No biological data is given. MECHANISM OF ACTION : Thrombin inhibitor.

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