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Arylsulfonamide-based matrix metalloprotease inhibitors
专利权人:
Claus Ehrhardt;Pascal Rigollier;Leslie Wighton McQuire;Olivier Rogel;Ruben Alberto Tommasi;Michael Shultz
发明人:
Claus Ehrhardt,Leslie Wighton McQuire,Pascal Rigollier,Olivier Rogel,Michael Shultz,Ruben Alberto Tommasi
申请号:
US12933988
公开号:
US08222424B2
申请日:
2009.03.23
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a compound of formula (I):said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
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