Duke University;University of Virginia Patent Foundation
发明人:
Anthony Filiano,Joanne Kurtzberg,Jonathan Kipnis
申请号：
US16772726
公开号：
US20200316039A1
申请日:
2018.12.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to compositions and methods for enhanced engraftment of hematopoietic cells into the brain, and to therapeutic methods of treating central nervous system (CNS) diseases and disorders in subjects where replacing CNS pot macrophages (including microglia) and other tissue-resident macrophages with donor cells would be beneficial. In particular, the present disclosure relates to the use of a microglia depleting agent to enhance engraftment of hematopoietic-derived macrophages in the brain of a subject undergoing hematopoietic cell transplantation, to treat a subject suffering from a leukodystrophy and undergoing hematopoietic cell transplantation, to treat a subject suffering from a disease mediated by microglial dysfunction and undergoing hematopoietic cell transplantation, and to related methods. The present disclosure also relates to detection within cell populations of beMcϕ and microglia signatures.
