BARONI, Maria Cristina,CABASSI, Clotilde Silvia,ROMANI, Antonello
申请号：
ES13828804
公开号：
ES2683392T3
申请日:
2013.12.30
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Peptide consisting of an ABCD-C'-B'-A 'sequence, where: unit A consists of 2 amino acids, and unit A' consists of 1 amino acid, both units B and B 'are Cys, each unit C it consists independently of amino acids, selected from both the group (a) of hydrophobic amino acids, and the group (b) of basic amino acids or hydrogen bonding amino acids； unit D is -Arg-Gly-, where: (i) said hydrophobic amino acids are selected from: Ala, Phe, Ileu, Leu, Pro, Tyr, Trp and Val； (ii) said basic amino acids are selected from: Lys, His, Arg； (iii) said hydrogen bonding amino acids are selected from Asn, Gln, Ser, Thr； and wherein the CDC 'substructure as a whole contains 5 to 9 alternating points between amino acid of group (a) and amino acid of group (b), or vice versa, where the peptide is in the cyclic form through the formation of a disulfide bridge between the two B units, and where the hydrophobic amino acids are between 30 and 50% of the total amount of amino acids in the peptide, said peptide is for use in the treatment of infections of the human or animal body caused by bacteria, fungi and / or yeasts.Péptido que consiste en una secuencia A-B-C-D-C'-B'-A', en donde: la unidad A consiste en 2 aminoácidos, y la unidad A' consiste en 1 aminoácido, ambas unidades B y B' son Cys, cada unidad C consiste independientemente en aminoácidos, seleccionados tanto del grupo (a) de aminoácidos hidrofóbicos, como del grupo (b) de aminoácidos básicos o aminoácidos formadores de enlaces de hidrógeno； la unidad D es -Arg-Gly-, en donde: (i) dichos aminoácidos hidrofóbicos se seleccionan de: Ala, Phe, Ileu, Leu, Pro, Tyr, Trp y Val； (ii) dichos aminoácidos básicos se seleccionan de: Lys, His, Arg； (iii) dichos aminoácidos formadores de enlaces de hidrógeno se seleccionan de Asn, Gln, Ser, Thr； y en donde la subestructura C-D-C' como un todo contiene de 5 a 9 puntos de alternancia entre aminoácido del grupo (a) y aminoácido del grupo (b), o viceversa, en donde el péptido está en la forma cíclic
