The present invention relates to novel herbal pharmaceutical compositions and method of preparing said herbal pharmaceutical compositions. Said novel composition along with therapeutic agents and pharmaceutically acceptable carriers, pharmaceutically acceptable bases or combinations thereof, is useful for the treatment of ano-rectal diseases, including hemorrhoids, anal fissures, fistula etc. The novel compositions possess properties to control inflammation by lowering levels of inflammatory cytokines and matrix metalloproteinases, prevent capillary bleeding and fragility in mammalians, particularly human beings and have wound healing properties.