Devices, systems and methods for the inactivation of pathogens such as viruses in a liquid medium containing products such as pharmaceutical compounds are presented. These are useful, for example, for the inactivation of viruses in liquids containing antibody pharmaceuticals, and make use of one or more of flow-through inactivation, plasmonic virus inactivation enhancement, mode matching between hydrodynamic flow profile and laser intensity profile, and nonlinear flow geometries. The methods allow flow-through pathogen inactivation while avoiding collateral damage to products to be decontaminated.
